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Updated: Jul 17, 2025

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
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Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

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A thorough and current study of miR-214-related targets in cancer

Bayu Indra Sukmana1, Sulieman Ibraheem Shelash Al-Hawary2, Munther Abosaooda3

  • 1Departement of Oral Biology, Lambung Mangkurat University, Banjarmasin, Indonesia.

Pathology, Research and Practice
|September 3, 2023
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in cancer. This review highlights microRNA-214 (miR-214) as a significant factor in tumor development and spread, primarily by inducing apoptosis in cancer cells.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer involves genetic anomalies affecting gene expression.
  • MicroRNAs (miRNAs) are non-coding RNAs regulating gene expression post-transcriptionally.
  • miRNAs influence tumor development by controlling key biological processes.

Purpose of the Study:

  • To review the multifaceted roles of microRNA-214 (miR-214) in neoplastic conditions.
  • To highlight miR-214's function as a modulator in cancer.
  • To discuss the link between miR-214 and tumor emergence and progression.

Main Methods:

  • Literature review of recent studies on miR-214 and cancer.
  • Analysis of miR-214's genomic location and relationship with the DNM3 gene.
  • Examination of miR-214's regulatory functions in cancer biology.

Main Results:

  • miR-214 is implicated in tumor development and metastasis.
  • miR-214, located near the DNM3 gene, plays a role in inducing apoptosis in cancer cells.
  • Recent studies link miR-214 to various aspects of tumorigenesis.

Conclusions:

  • miR-214 exhibits complex and multifaceted functions as a cancer modulator.
  • Understanding miR-214's role is crucial for cancer research and therapy.
  • miR-214's primary function involves promoting apoptosis in cancerous cells.
Keywords:
Cancer progressionMicroRNA-214Non-coding RNAOncogenesis

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