Related Experiment Videos
Pulmonary cytoplasmic hyalin resembling Mallory's alcoholic hyalin in the liver
Abstract:
Sixty-three consecutive autopsy cases of interstitial fibrosis of the lung, 6 cases of organizing pneumonia, 14 of pneumocystis pneumonia, and 20 of acute bacterial pneumonia complicating as a terminal illness listed in our Department of Pathology during a period from 1978 to 1983 were surveyed for Mallory body-like cytoplasmic hyalins in the alveolar cells. We found the hyalins in 10 of 63 cases (15.9%) with interstitial fibrosis of the lung and one of 6 cases with organizing pneumonia. Seven of the former 10 had an associated malignancy; 3 esophageal cancers, 2 lung cancers, and 2 leukemias. Five of the seven patients received an irradiation for treatment of their malignancies, subsequently developed interstitial fibrosis of the lung. Among the remaining 3 of the 10, one showed diffuse interstitial fibrosis associated with rheumatoid arthritis and two had an idiopathic type of diffuse pulmonary fibrosis. There was only one case in which the pulmonary hyalins were found in the absence of extensive interstitial fibrosis within small organizing foci of peribronchial and subpleural location. Pulmonary hyalins showed the same conventional staining properties and ultrastructural features as Mallory's alcoholic hyalins found in the liver, but did not reveal a simultaneous association with the hepatic hyalins. Pulmonary hyalins frequently stained positively with monoclonal anti-cytokeratin antibodies, more strongly at their periphery. Pulmonary hyalins were considered to be a non-specific reaction of alveolar cells to injuries, mostly in association with the pulmonary fibrosis of any etiology but not the hepatic hyalins.
Insights
Pulmonary hyalins, similar to Mallory bodies, were found in lung tissues, particularly with interstitial fibrosis. These hyalins are a non-specific cellular response to lung injury, not linked to liver hyalins.
Area of Science:
- Pulmonary Pathology
- Cellular Biology
- Oncology
Background:
- Mallory body-like cytoplasmic hyalins are typically found in liver cells.
- Their presence in lung tissue, specifically alveolar cells, is less understood.
Purpose of the Study:
- To investigate the occurrence and characteristics of Mallory body-like cytoplasmic hyalins in various lung pathologies.
- To determine the association of pulmonary hyalins with interstitial lung diseases, malignancy, and other conditions.
Main Methods:
- Autopsy cases (n=99) with interstitial fibrosis, organizing pneumonia, pneumocystis pneumonia, and bacterial pneumonia were retrospectively analyzed.
- Immunohistochemical staining using monoclonal anti-cytokeratin antibodies was performed.
- Ultrastructural examination and conventional staining properties were assessed.
Main Results:
- Pulmonary hyalins were identified in 15.9% of interstitial fibrosis cases and one organizing pneumonia case.
- Seven of ten patients with pulmonary hyalins had associated malignancies (esophageal, lung, leukemia), with five receiving prior irradiation.
- Pulmonary hyalins shared staining and ultrastructural features with hepatic Mallory's hyalins but were not simultaneously present with them and stained positively for cytokeratin.
Conclusions:
- Pulmonary hyalins represent a non-specific reaction of alveolar cells to lung injury, frequently associated with pulmonary fibrosis of diverse etiologies.
- Their presence is not indicative of hepatic hyalin involvement.