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Pertussis in Mexico from 2000 to 2019: A real-world study of incidence, vaccination coverage, and vaccine

Gilberto Sánchez-González1, Gerardo Luna-Casas2, Cesar Mascareñas3

  • 1Centro de Investigación Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Av Universidad 655, Santa María Ahuacatitlán, 62100 Cuernavaca, Morelos, Mexico.

Vaccine
|September 4, 2023
PubMed
Abstract

Insights

Mexico

Area of Science:

  • Immunology
  • Public Health
  • Epidemiology

Background:

  • Mexico transitioned from whole-cell pertussis (wP) to acellular pertussis (aP) vaccines in 2007.
  • The national immunization program includes a primary series and a booster dose.

Purpose of the Study:

  • To assess pertussis incidence, vaccination coverage, and vaccine effectiveness (VE) in Mexico from 2000-2019.
  • To evaluate the impact of the vaccine switch on pertussis epidemiology.

Main Methods:

  • Retrospective study utilizing Mexican National Databases of Health and population surveillance (2000-2019).
  • Analysis of pertussis incidence, infant vaccination coverage, and VE in children based on age groups for primary series and booster doses.

Main Results:

  • Pertussis incidence peaked in 2012, 2015, and 2016.
  • Vaccine effectiveness for wP (2000-2007) was 96.4%; for aP (2008-2019) it was 95.7%.
  • Coverage decreased with subsequent doses in the primary series.

Conclusions:

  • Both whole-cell pertussis (wP) and acellular pertussis (aP) vaccines demonstrated high effectiveness in Mexico.
  • Sustained high vaccine effectiveness is crucial for pertussis control.
Keywords:
CoverageEffectivenessIncidenceMexicoPertussisVaccine

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