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Central blood pressure obtained by cuff-based oscillometry as a determinant of left ventricular hypertrophy in

Mohamed Aboel-Kassem F Abdelmegid1, Doaa A Fouad1, Nardeen W M Beshay1

  • 1Cardiovascular Medicine Department, Assiut University Heart Hospital, Assiut University.

Blood Pressure Monitoring
|September 4, 2023
PubMed

Insights

Central systolic blood pressure (SBP) measured non-invasively is a better indicator of left ventricular hypertrophy (LVH) in hypertensive patients than brachial SBP. Increased central SBP and pulse wave velocity (PWV) with aging are more pronounced in patients with LVH.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Diagnostic Imaging

Background:

  • Conflicting data exist on central blood pressure (CBP) vs. brachial blood pressure (BP) for predicting hypertension-mediated organ damage.
  • Most existing data on CBP use applanation tonometry, which has complexities.
  • Non-invasive oscillometric CBP measurement offers a simpler alternative for assessing organ damage.

Purpose of the Study:

  • To investigate left ventricular hypertrophy (LVH) diagnostic factors.
  • To evaluate the utility of non-invasive oscillometric CBP measurement and derived hemodynamic indices.
  • To compare CBP with brachial BP as indicators of LVH.

Main Methods:

  • Cross-sectional study of 300 hypertensive patients (mean age 55.3 years, 51.7% obese).
  • Measurements included brachial BP (mercury sphygmomanometer), CBP (Mobil-O-Graph), and left ventricular (LV) mass (echocardiography).
  • LVH defined by LV mass index/height 2.7 and relative wall thickness.

Main Results:

  • Central systolic BP (SBP) and pulse wave velocity (PWV) were significant determinants of LVH.
  • Optimally controlled brachial BP was a negative determinant for LVH.
  • Central SBP demonstrated acceptable diagnostic performance for LVH (AUC = 0.722).

Conclusions:

  • Estimated central SBP using Mobil-O-Graph correlated significantly higher with LVH than brachial SBP.
  • Aging-related increases in central SBP and PWV were more pronounced in patients with LVH.
Abstract

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