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An Overview of Current Glaucomatous Trabecular Meshwork Models.
Juliette Buffault1,2,3, Françoise Brignole-Baudouin2,4, Antoine Labbé1,2,3
1Department of Ophthalmology III, Quinze-Vingts National Ophthalmology Hospital, IHU Foresight, Paris, France.
Current Eye Research
|September 4, 2023
Summary
Alternative models for studying the trabecular meshwork (TM) are crucial for understanding open-angle glaucoma. These models offer promising alternatives to animal studies for developing new therapeutic strategies.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Tissue Engineering
Background:
- The trabecular meshwork (TM) regulates aqueous humor outflow, and its dysfunction contributes to open-angle glaucoma.
- Understanding TM degeneration mechanisms is vital for treating this leading cause of irreversible blindness.
- Current drug development for TM-related conditions is limited.
Purpose of the Study:
- To review existing alternative experimental models for studying the TM.
- To assess the potential of these models in advancing glaucoma research.
- To explore their utility in developing novel therapeutic strategies.
Main Methods:
- Comprehensive literature review of alternative *in vitro* models for TM research.
- Analysis of advancements in 3D cell culture and tissue engineering for TM studies.
- Evaluation of model translatability and limitations compared to traditional methods.
Main Results:
- Traditional animal models have limitations in ethical considerations and human translatability.
- Alternative *in vitro* models, including 3D cultures, show promise in mimicking TM complexity.
- These models are emerging as valuable tools for preclinical screening and understanding glaucomatous trabeculopathy.
Conclusions:
- Alternative models are essential for advancing the understanding of open-angle glaucoma pathophysiology.
- They offer a reduced reliance on animal experimentation for TM research.
- These models hold significant potential for developing targeted therapeutic strategies for glaucoma.
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