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Clinically informative microRNAs for SARS-CoV-2 infection
Sercan Ergün1,2, Ramamoorthy Sankaranarayanan3, Nina Petrović4,5
1Department of Medical Biology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
Epigenomics
|September 4, 2023
Summary
MicroRNAs (miRNAs) play a crucial role in regulating gene activity during SARS-CoV-2 infection. Understanding these molecules offers insights into COVID-19
Area of Science:
- Molecular Biology
- Virology
- Genetics
Background:
- COVID-19, a viral respiratory illness, is caused by SARS-CoV-2.
- MicroRNAs (miRNAs) are key regulators of gene expression and cellular homeostasis.
- Both viral and host miRNAs are implicated in the host-pathogen interactions during SARS-CoV-2 infection.
Purpose of the Study:
- To review the effects and biological roles of miRNAs in SARS-CoV-2 pathogenicity.
- To explore the involvement of miRNAs in the SARS-CoV-2 life cycle.
- To discuss the therapeutic potential of miRNAs for treating COVID-19.
Main Methods:
- Literature review of studies investigating miRNA involvement in SARS-CoV-2.
- Analysis of mechanisms by which miRNAs influence viral infection and host response.
- Synthesis of current knowledge on miRNA-based therapeutic strategies.
Main Results:
- miRNAs modulate host immune responses and viral replication.
- Specific miRNAs are associated with disease severity and progression.
- miRNAs can be targeted for antiviral therapies.
Conclusions:
- miRNAs are critical players in the pathophysiology of SARS-CoV-2 infection.
- Targeting miRNAs presents a promising avenue for novel COVID-19 therapeutics.
- Further research into miRNA-host-virus interactions is warranted.
