Trends in long term growth outcome: comparison of two birth cohorts (year 2007-08 and year 2015-16)
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Published on: September 17, 2019
Kallem Venkat Reddy1, Challa V S Lakshmi2, Sai Kiran1
1DNB Resident, Fernandez Hospital Hyderguda, Hyderabad, India.
Insights
Very low birth weight (VLBW) infants showed improved growth outcomes in a later cohort. This study found significantly higher weight and length, and reduced underweight incidence in VLBW infants from the 2015-16 cohort compared to the 2007-08 cohort.
Area of Science:
- Neonatalogy
- Pediatric Growth and Development
- Public Health
Background:
- Very low birth weight (VLBW) infants represent a significant proportion of neonatal mortality.
- Understanding long-term growth trajectories is crucial for improving VLBW infant outcomes.
Purpose of the Study:
- To compare the long-term growth outcomes of VLBW infants between two distinct birth cohorts (2007-08 and 2015-16).
- To evaluate changes in weight, length, and the incidence of underweight, stunting, and microcephaly over time.
Main Methods:
- A cross-sectional observational study design was employed.
- Neonatal and perinatal data were collected from trial data and patient case files.
- Growth outcomes (weight and length) were assessed at corrected ages of 12-18 months.
Main Results:
- Infants in the 2015-16 cohort (cohort 2) demonstrated significantly higher weight and length compared to the 2007-08 cohort (cohort 1).
- The incidence of underweight was significantly lower in cohort 2.
- No significant differences were observed in the rates of stunting or microcephaly between the two cohorts.
Conclusions:
- Improved clinical care or environmental factors likely contributed to better growth outcomes in VLBW infants in the more recent cohort.
- Targeted interventions may be beneficial for reducing underweight incidence in VLBW populations.
Abstract:
Very low birth weight (VLBW) infants comprise between 4% and 8% of live-births and about one-third of deaths during the neonatal period. The objective of the study is to evaluate and compare the long-term growth outcomes of VLBW infants among two different birth cohorts: Cohort 2007-08 (cohort 1) and cohort 2015-16 (cohort 2), in a cross-sectional observational study. The neonatal and perinatal data of cohort 1 was collected from available trial data and the same data from cohort 2 was collected from patient case files and patient history. The primary outcome of the study was to compare the growth outcomes of VLBW infants attending the follow-up clinic between 12 and 18 months of corrected age from two different birth cohorts. Respectively, 238 and 268 infants were eligible for inclusion in cohort 1 and 2. Among the eligible infants, 148 infants in cohort 1 and 178 infants in cohort 2 were available for primary outcome assessment during the recruitment phase. The weight and length at corrected age (12 to 18 months) is significantly higher in cohort 2 compared to that in cohorts 1 although the mean age at assessment is similar between the two groups. There is a significant reduction in the incidence of underweight in infants that belonged to cohort 2. The proportions of infants who are underweight at follow-up were significantly lower in cohort 2 when compared to cohort 1, and there were no significant differences in the incidence of stunting and microcephaly among both the cohorts.
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