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The function of Foxp1 represses β-adrenergic receptor transcription in the occurrence and development of bladder

Zhenshan Ding1, Binbin Jiao2, Xuelong Chen3

  • 1Department of Urology, China-Japan Friendship Hospital, No. 2, Yinghua East Road, Chaoyang District, Beijing 100029, China.

Open Medicine (Warsaw, Poland)
|September 4, 2023
PubMed

Insights

Forkhead box protein P1 (FOXP1) promotes bladder cancer development by enhancing the Warburg effect and suppressing beta-adrenoceptor (β-AR) expression, offering potential therapeutic targets.

Area of Science:

  • Oncology
  • Molecular Biology

Background:

  • Bladder cancer is a prevalent malignancy.
  • Abnormal FOXP1 expression is observed in various cancers, including renal cell carcinoma and endometrial cancer.

Purpose of the Study:

  • To investigate the role of Forkhead box protein P1 (FOXP1) in bladder cancer occurrence and progression.
  • To elucidate the underlying molecular mechanisms involving the Warburg effect, beta-adrenoceptor (β-AR), and STAT3 signaling.

Main Methods:

  • Analysis of FOXP1 mRNA and protein expression in bladder cancer tissues and cell lines.
  • In vitro studies to assess the impact of FOXP1 on cell growth and the Warburg effect.
  • Chromatin immunoprecipitation sequencing (ChIP-seq) to identify FOXP1 binding sites.
  • Investigation of β-AR's role in modulating FOXP1's effects.

Main Results:

  • FOXP1 expression was elevated in bladder cancer tissues compared to normal tissues.
  • Higher FOXP1 expression correlated with poorer overall survival (OS) and disease-free survival (DFS).
  • FOXP1 promoted bladder cancer cell growth, increased the Warburg effect, and suppressed β-AR expression.
  • β-AR partially reversed FOXP1's effects on cell growth and the Warburg effect via STAT3 activity.

Conclusions:

  • FOXP1 drives bladder cancer progression through the Warburg effect and STAT3 activation, partly by repressing β-AR transcription.
  • Targeting FOXP1 presents a potential therapeutic strategy for bladder cancer.
Keywords:
Foxp1STAT3Warburg effectbladder cancerβ-AR

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