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Related Experiment Video

Updated: Jul 17, 2025

Laparoscopic Anterior Right Hepatectomy: A Single-Center Experience
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Low anterior resection syndrome.

Seung-Bum Ryoo1,2

  • 1Division of Colorectal Surgery, Department of Surgery Seoul National University Hospital, Seoul National University College of Medicine Seoul Korea.

Annals of Gastroenterological Surgery
|September 4, 2023
PubMed
Summary

Low anterior resection syndrome (LARS) causes significant defecatory dysfunction after rectal cancer surgery. Ramosetron shows promise as a safe and effective treatment for major LARS symptoms.

Keywords:
compliancedefecatory functionlow anterior resection syndromequality of liferectal cancer

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Area of Science:

  • Gastroenterology
  • Colorectal Surgery
  • Oncology

Background:

  • Low anterior resection syndrome (LARS) presents as a common and distressing functional defecatory disorder following sphincter-saving rectal cancer surgery.
  • Symptoms include fecal urgency, frequency, and incontinence, significantly impacting patient quality of life.
  • Current definitive treatments for LARS are lacking, necessitating further research into effective management strategies.

Purpose of the Study:

  • To investigate the potential of ramosetron, a 5-Hydroxytryptamine (5-HT) receptor antagonist, in alleviating symptoms associated with major LARS.
  • To evaluate the safety and efficacy of ramosetron as a therapeutic option for patients experiencing LARS after rectal cancer surgery.

Main Methods:

  • A randomized-controlled trial was conducted to assess the effects of ramosetron.
  • The study focused on patients diagnosed with major LARS following sphincter-saving procedures for rectal cancer.
  • The LARS score questionnaire, validated in multiple languages, was used to confirm LARS severity.

Main Results:

  • The randomized-controlled trial indicated that ramosetron is a safe and effective treatment for patients suffering from major LARS.
  • Ramosetron demonstrated potential in relieving key symptoms of LARS, offering a new therapeutic avenue.

Conclusions:

  • Ramosetron represents a promising pharmacological intervention for managing major Low anterior resection syndrome.
  • Further research and development of novel treatments are crucial to address the unmet needs in LARS management.