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Updated: Jul 17, 2025

Evaluation of Exon Inclusion Induced by Splice Switching Antisense Oligonucleotides in SMA Patient Fibroblasts
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Targeted splicing therapy: new strategies for colorectal cancer

Yifeng Zheng1, Guoqiang Zhong1, Chengcheng He1

  • 1Department of Gastroenterology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.

Frontiers in Oncology
|September 4, 2023
PubMed

Insights

Alternative splicing (AS) generates tumor-specific variants, driving cancer progression. Understanding aberrant splicing in colorectal cancer (CRC) is key to developing targeted splicing therapies.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • RNA splicing is crucial for gene expression, regulating cell functions like proliferation and differentiation.
  • Aberrant RNA splicing and alternative splicing (AS) are linked to tumor development and progression.
  • AS generates oncogenic splicing variants that promote tumor growth and affect cancer biology.

Purpose of the Study:

  • To review abnormal splicing events in colorectal cancer (CRC).
  • To highlight tumor-associated splicing variants resulting from AS.
  • To provide insights into CRC-targeted splicing therapy.

Main Methods:

  • Literature review of studies on RNA splicing and colorectal cancer.
  • Analysis of alternative splicing mechanisms in tumorigenesis.
  • Focus on oncogenic splicing isoforms in CRC.

Main Results:

  • Alternative splicing (AS) is a significant driver of tumor progression in CRC.
  • AS contributes to increased oncogenic isoforms and decreased normal isoforms.
  • Aberrant splicing impacts CRC cell proliferation, invasion, apoptosis resistance, and drug sensitivity.

Conclusions:

  • Abnormal splicing, particularly AS, plays a critical role in colorectal cancer progression.
  • Targeting aberrant splicing events presents a promising therapeutic strategy for CRC.
  • Further research into CRC-specific splicing variants can guide the development of novel splicing therapies.
Keywords:
alternative splicingcolorectal cancersplicing isoformtargeted splicing therapytumor-associated splicing variants

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