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Updated: Jul 17, 2025

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
Published on: July 25, 2013
Toward the appropriate interpretation of Alphafold2
Tian Xu1, Qin Xu2, Jianyong Li1
1Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.
Abstract:
In life science, protein is an essential building block for life forms and a crucial catalyst for metabolic reactions in organisms. The structures of protein depend on an infinity of amino acid residues' complex combinations determined by gene expression. Predicting protein folding structures has been a tedious problem in the past seven decades but, due to robust development of artificial intelligence, astonishing progress has been made. Alphafold2, whose key component is Evoformer, is a typical and successful example of such progress. This article attempts to not only isolate and dissect every detail of Evoformer, but also raise some ideas for potential improvement.
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