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Ginsenoside Rg3 inhibits the malignant progression of cervical cancer cell by regulating AKT2 expression

Hui Liu1, Tingting Xie2, Yuan Liu1

  • 1Department of Pharmacy, Shangqiu First People's Hospital, Shangqiu, 476000, China.

Heliyon
|September 4, 2023
PubMed

Insights

Ginsenoside Rg3 inhibits cervical cancer (CC) progression by suppressing cell proliferation, migration, and invasion. This compound targets AKT serine/threonine kinase 2 (AKT2) expression, offering a potential therapeutic strategy for cervical cancer treatment.

Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Background:

  • Ginsenoside Rg3 exhibits anticancer properties in multiple cancers.
  • The specific mechanisms of ginsenoside Rg3 in cervical cancer (CC) are not fully understood.

Purpose of the Study:

  • To investigate the effects of ginsenoside Rg3 on cervical cancer cell development.
  • To elucidate the molecular mechanisms underlying ginsenoside Rg3's action in CC, focusing on AKT2.

Main Methods:

  • Cell Counting Kit-8, colony formation, wound healing, transwell, and tube formation assays were used to assess cell proliferation, migration, invasion, and angiogenesis.
  • The expression of AKT serine/threonine kinase 2 (AKT2) was analyzed in CC cells treated with ginsenoside Rg3.

Main Results:

  • Ginsenoside Rg3 significantly suppressed CC cell proliferation, migration, invasion, and in vitro angiogenesis.
  • Treatment with ginsenoside Rg3 led to a decrease in AKT2 expression in CC cells.
  • Ginsenoside Rg3 partially counteracted the effects of AKT2 overexpression on CC cell behavior.

Conclusions:

  • Ginsenoside Rg3 demonstrates inhibitory effects on cervical cancer progression.
  • The mechanism involves the regulation of AKT2 expression, suggesting AKT2 as a potential therapeutic target for cervical cancer.
Keywords:
AKT2Cervical cancerGinsenoside Rg3InvasionMigrationProliferation

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