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Related Experiment Videos

Atrial septal defects that present in infancy.

L T Mahoney, S C Truesdell, T R Krzmarzick

    American Journal of Diseases of Children (1960)
    |November 1, 1986
    PubMed
    Summary

    Most infants with symptomatic atrial septal defect (ASD) can be managed medically. This approach allows time for spontaneous closure, which occurs in a significant percentage of cases, avoiding unnecessary surgery.

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    Area of Science:

    • Pediatric Cardiology
    • Congenital Heart Disease
    • Echocardiography

    Background:

    • Isolated secundum atrial septal defect (ASD) diagnosis in infancy is rare.
    • Infants with ASD often present with congestive heart failure rather than typical clinical features.
    • Large left-to-right shunts may not always present with obvious clinical signs of ASD.

    Purpose of the Study:

    • To evaluate the clinical presentation and management outcomes of infants diagnosed with isolated secundum ASD.
    • To determine the rate of spontaneous closure and the efficacy of medical management in this population.
    • To identify predictors of spontaneous closure in infants with ASD.

    Main Methods:

    • Retrospective study of 26 infants with ASD confirmed by cardiac catheterization.
    • Analysis of clinical presentation, management strategies (medical vs. surgical), and long-term outcomes.
    • Assessment of spontaneous closure rates and factors influencing it.

    Main Results:

    • 39% of patients experienced spontaneous closure of their ASD between ages 2 and 8 years.
    • 12 patients underwent surgical closure at a mean age of 4 years.
    • No presenting variables predicted spontaneous closure; most patients responded well to medical management.

    Conclusions:

    • Infants with symptomatic ASD can often be managed medically, facilitating observation for spontaneous closure.
    • Medical management is successful for most infants, with a high rate of spontaneous closure observed.
    • Surgical intervention may be delayed or avoided in many cases, given the potential for natural resolution.

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