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Related Experiment Video

Updated: May 3, 2026

One Minute, Sub-One-Watt Photothermal Tumor Ablation Using Porphysomes, Intrinsic Multifunctional Nanovesicles

One Minute, Sub-One-Watt Photothermal Tumor Ablation Using Porphysomes, Intrinsic Multifunctional Nanovesicles

Published on: September 17, 2013

Polymer Vesicles with Integrated Photothermal Responsiveness.

Yingtong Luo¹, Hanglong Wu¹, Xuan Zhou²

¹Bio-Organic Chemistry, Institute of Complex Molecular Systems (ICMS), Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.

Journal of the American Chemical Society

|September 4, 2023

Summary

This summary is machine-generated.

Researchers developed novel near-infrared (NIR) light-responsive polymer vesicles for biomedical use. These functionalized vesicles exhibit excellent photothermal properties and cargo loading, showing promise for synergistic cancer therapy.

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Published on: June 8, 2016

Area of Science:

Materials Science
Polymer Chemistry
Nanotechnology

Background:

Functionalized polymer vesicles offer biocompatibility and responsiveness for biomedical applications.
Near-infrared (NIR) light-triggered photothermal polymer vesicles are underexplored.
Developing novel materials for targeted therapies is crucial.

Purpose of the Study:

To design and synthesize NIR light-mediated photothermal polymer vesicles.
To evaluate their photothermal performance and potential for drug delivery.
To establish a robust platform for synergistic anticancer treatment.

Main Methods:

Synthesized a novel small molecule (PTA) with NIR photothermal features and molecular rotor function (TPE).
Incorporated PTA into poly(ethylene glycol)-poly(trimethylene carbonate) block copolymers.
Utilized density functional theory (DFT) for design validation and self-assembly for vesicle formation.

Main Results:

Achieved significant temperature increase (to 56 °C) in aqueous solutions upon 10 min NIR irradiation.
Demonstrated intact photothermal properties and bilayer structure post-irradiation, confirming robustness.
Successfully encapsulated both hydrophobic (Cy7) and hydrophilic (Sulfo-Cy5) cargo within the vesicles.

Conclusions:

The developed polymer vesicles exhibit efficient NIR-triggered photothermal activity and good structural integrity.
These vesicles demonstrate versatile cargo loading capabilities for hydrophobic and hydrophilic agents.
The functionalized vesicles present a promising platform for advanced synergistic photothermal and drug delivery therapies in cancer treatment.