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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Updated: Jul 17, 2025

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Non-Coding RNA in Cholangiocarcinoma: An Update.

Jiehan Li1, Haolin Bao1, Ziyue Huang1

  • 1Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, 150086 Harbin, Heilongjiang, China.

Frontiers in Bioscience (Landmark Edition)
|September 4, 2023
PubMed
Summary

Cholangiocarcinoma (CCA) progression is influenced by non-coding RNAs (ncRNAs). Understanding long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) mechanisms offers new diagnostic and therapeutic strategies for this aggressive cancer.

Keywords:
cholangiocarcinomacircular RNAcompetitive endogenous RNAepigeneticlong non-coding RNAnon-coding RNAsignaling pathways

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cholangiocarcinoma (CCA) is a highly malignant and increasingly common cancer.
  • Late diagnosis and metastasis contribute to poor patient survival rates.
  • Identifying novel biomarkers and therapeutic targets is crucial for improving CCA outcomes.

Purpose of the Study:

  • To review the molecular mechanisms of long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) in CCA progression.
  • To discuss the potential clinical applications of these non-coding RNAs in CCA diagnosis and treatment.

Main Methods:

  • Literature review of recent studies on lncRNAs and circRNAs in CCA.
  • Analysis of ncRNA regulatory roles in CCA pathogenesis.
  • Evaluation of clinical relevance for biomarkers and therapeutic targets.

Main Results:

  • Aberrantly expressed lncRNAs and circRNAs significantly regulate CCA development.
  • These ncRNAs function through epigenetic modifications, miRNA sponging, and signaling pathway modulation.
  • Specific lncRNAs and circRNAs show promise as diagnostic and prognostic biomarkers.

Conclusions:

  • lncRNAs and circRNAs are key players in CCA molecular mechanisms.
  • Targeting these ncRNAs presents novel therapeutic opportunities for CCA.
  • Further research can translate these findings into clinical practice for improved patient care.