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Moringa induces its beneficial effect via hormesis
Edward J Calabrese1, Gaurav Dhawan2, Rachna Kapoor3
1Department of Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA01003USA.
Nutrition Research Reviews
|September 4, 2023
Summary
Moringa oleifera, an Indian herb, demonstrates antioxidant and anti-inflammatory effects. Its beneficial properties, particularly in slowing age-related diseases, stem from its ability to induce hormetic dose responses.
Area of Science:
- Pharmacology and Toxicology
- Plant Science
- Biomedical Research
Background:
- Moringa oleifera, a traditional Indian herb, is recognized for its antioxidant, anti-inflammatory, and chemoprotective properties.
- Extensive research has explored its potential in protecting biological systems from oxidative stress and mitigating age-related diseases.
- Moringa extracts have also shown protective effects against oxidative and saline stresses in plants, exhibiting hormetic dose-response patterns.
Purpose of the Study:
- To provide an integrated and mechanistically based assessment of Moringa oleifera extracts.
- To demonstrate that moringa extracts commonly induce hormetic dose responses.
- To elucidate the role of hormesis in the beneficial effects of moringa.
Main Methods:
- Review and analysis of existing studies on Moringa oleifera extracts.
- Mechanistic assessment of the dose-response patterns observed in various biomedical and plant models.
- Integration of findings to establish a comprehensive understanding of moringa's effects.
Main Results:
- Moringa extracts consistently induce hormetic dose responses across diverse models.
- A significant portion of the beneficial effects attributed to moringa are mediated by its action as a hormetic agent.
- This hormetic effect contributes to its protective capabilities against oxidative stress and potential in managing age-related conditions.
Conclusions:
- The beneficial effects of Moringa oleifera are largely attributable to its capacity to induce hormesis.
- Understanding the hormetic mechanisms of moringa provides a unified explanation for its diverse protective effects.
- This highlights the therapeutic and preventative potential of moringa as a hormetic agent in both human health and agriculture.
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