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Cardiotoxicity of Breast Cancer Chemotherapy
Sacha A Roberts1, William H Frishman1
1From the Department of Medicine, NewYork-Presbyterian/Weill Cornell Medical Center, New York, NY.
Cardiology in Review
|September 4, 2023
Summary
This review examines cardiotoxicity from breast cancer treatments like anthracyclines and HER2 antagonists. It discusses monitoring and preventing chemotherapy-induced cardiac dysfunction in patients.
Area of Science:
- Oncology
- Cardiology
- Pharmacology
Background:
- Breast cancer is a leading cause of malignancy in women.
- Effective treatments often have significant side effects.
- Chemotherapeutic agents can cause myocardial tissue toxicity.
Purpose of the Study:
- To review literature on cardiotoxicity of specific breast cancer agents.
- To discuss monitoring and prevention strategies for cardiac injury.
- To inform providers and patients about treatment-related cardiac risks.
Main Methods:
- Literature review of existing studies.
- Synthesis of reported data on cardiotoxicity.
- Analysis of monitoring and prevention guidelines.
Main Results:
- Anthracyclines and HER2 antagonists are associated with cardiotoxicity.
- Cardiotoxicity can manifest as cardiac injury and dysfunction.
- Monitoring protocols and preventive measures are crucial.
Conclusions:
- Understanding cardiotoxicity is vital for breast cancer patient care.
- Proactive monitoring and prevention can mitigate cardiac risks.
- Further research may refine management strategies.
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