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Aging-related decrease of histone methyltransferase SUV39H1 in adipose-derived stem cells enhanced SASP.

Ruoyu Li¹, Yungshan Teng¹, Yuqing Guo¹

¹Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, PR China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, PR China.

Mechanisms of Ageing and Development

|September 4, 2023

Summary

This summary is machine-generated.

Suppressor of variegation 3-9 homolog 1 (SUV39H1) inhibits the senescence-associated secretory phenotype (SASP) by regulating chromatin, offering new insights into aging and inflammation.

Keywords:

Aging Histone methylation SASP SUV39H1

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Area of Science:

Epigenetics and Molecular Biology
Aging Research
Cellular Senescence

Background:

Aging is linked to chronic inflammation, termed 'inflammaging'.
Cellular senescence involves a senescence-associated secretory phenotype (SASP) with inflammatory factors.
Epigenetic regulation, particularly chromatin structure, influences SASP.

Purpose of the Study:

Investigate the role of SUV39H1 in aging and its epigenetic regulation of SASP.
Clarify the controversial function of SUV39H1 in aging.

Main Methods:

Utilized C57BL/6J CAG-Cre; SUV39H1^fl/fl knockout mice.
Employed an irradiation-induced cellular senescence model.
Conducted in vivo and in vitro experiments.

Main Results:

SUV39H1 levels decrease with aging.
SUV39H1 acts as an inhibitor of SASP, specifically IL-6, MCP-1, and Vcam-1.
SUV39H1 alters H3K9me3 enrichment in the promoter regions of SASP factors.

Conclusions:

SUV39H1 plays a crucial role in the epigenetic regulation of SASP during aging.
Findings provide novel insights into the mechanisms linking epigenetics, aging, and inflammation.