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SALpingectomy for STERilisation (SALSTER): study protocol for a Swedish multicentre register-based randomised
Leonidas Magarakis1, Annika Idahl2, Karin Sundfeldt3,4
1Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden leonidas.magarakis@gu.se.
BMJ Open
|September 4, 2023
Summary
Salpingectomy is a safe alternative to tubal ligation for sterilization, potentially reducing ovarian cancer risk. The SALSTER trial provides evidence for informed patient decisions on this laparoscopic procedure.
Area of Science:
- Gynecology
- Surgical Oncology
- Reproductive Health
Background:
- Salpingectomy is increasingly used for sterilization, but its safety and benefits compared to tubal ligation are not fully established.
- Ovarian cancer precursor lesions in fallopian tubes suggest salpingectomy may reduce incidence.
- Existing safety data are limited, with a lack of randomized laparoscopic trials.
Purpose of the Study:
- To evaluate the safety and efficacy of laparoscopic opportunistic salpingectomy compared to tubal ligation for sterilization.
- To provide high-quality evidence for clinicians and patients regarding the risk-benefit balance of salpingectomy.
Main Methods:
- The SALSTER trial is a national, register-based, randomized controlled non-inferiority trial.
- 968 women under 50 desiring laparoscopic sterilization were randomized to salpingectomy or tubal ligation.
- Primary outcomes include postoperative complications and age at menopause; ovarian function is assessed via anti-Müllerian hormone levels.
Main Results:
- The SALSTER trial is ongoing and results are pending.
- This study aims to provide definitive data on the safety of laparoscopic salpingectomy.
Conclusions:
- The SALSTER trial will offer crucial evidence to guide clinical practice and patient choice regarding salpingectomy for sterilization.
- Results will inform the gynecological community on the comparative safety of salpingectomy versus tubal ligation.
