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[Keloid nomogram prediction model based on weighted gene co-expression network analysis and machine learning].

Zhengyu Li¹, Baohua Tian¹, Haixia Liang¹

¹College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, P. R. China.

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi

|September 4, 2023

Summary

This study identifies four key genes (HGF, SDC4, ENPP2, RND3) as diagnostic markers for keloids. A nomogram prediction model was developed for early keloid risk assessment in trauma patients.

Keywords:

Keloids Least absolute shrinkage and selection operator Nomogram prediction model Support vector machine-recursive feature elimination Weighted gene co-expression network analysis

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Area of Science:

Dermatology and Bioinformatics
Oncology
Molecular Biology

Context:

Keloids, benign skin tumors from excessive connective tissue proliferation, pose challenges in management.
Accurate keloid risk prediction and early diagnosis are crucial for effective patient care.
Existing diagnostic methods require improvement for timely intervention.

Purpose:

To identify reliable diagnostic markers for keloids.
To develop a predictive nomogram model for keloid risk assessment.
To explore potential biological pathways involved in keloid development.

Summary:

Analyzed four keloid gene expression datasets using WGCNA, differential expression, and network analysis to identify 37 core genes.
Applied LASSO and SVM-RFE machine learning algorithms to pinpoint four diagnostic markers: HGF, SDC4, ENPP2, and RND3.
Constructed and validated a nomogram prediction model demonstrating high accuracy, calibration, and clinical utility.

Impact:

The developed nomogram model shows significant potential for early clinical diagnosis of keloids.
Identified key genes provide insights into keloid pathogenesis.
The model offers an improved strategy for keloid risk stratification and management.