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Published on: January 12, 2018
Preterm births prevalence during the COVID-19 pandemic in Brazil: results from the national database
Charles M'poca Charles1,2, Luiz Alves Souza Neto3,4, Camila Ferreira Soares5
1Department of Obstetrics and Gynecology, University of Campinas, Campinas, SP, Brazil.
Insights
The COVID-19 pandemic saw a slight increase in preterm births in Brazil, with a 4% rise in 2020 and 2% in 2021. This trend varied regionally, with the South showing the highest increase and the North a decrease.
Area of Science:
- Public Health
- Epidemiology
- Reproductive Health
Background:
- The COVID-19 pandemic significantly disrupted global health systems, particularly sexual and reproductive health services.
- Previous studies from high-income countries indicated changes in preterm birth rates during the pandemic.
Purpose of the Study:
- To investigate the impact of the COVID-19 pandemic on preterm birth rates at a national level in Brazil.
- To compare preterm birth numbers during the pandemic (2020-2021) with pre-pandemic years.
Main Methods:
- A population-based cross-sectional study using live birth data from Brazil's Live Birth Information System (SINASC) from 2017 to 2021.
- Propensity score weighting analysis was employed to estimate the odds ratio (OR) of preterm deliveries, adjusting for sociodemographic variables.
Main Results:
- Preterm birth prevalence slightly increased during the pandemic (11.32% in 2021 vs. 11.09% in 2019).
- Adjusted analysis revealed a significant increase in preterm births: 4% in 2020 and 2% in 2021 compared to 2019.
- Regional variations were observed, with the South region showing the highest OR increase, while the North region experienced a significant reduction in preterm births.
Conclusions:
- The COVID-19 pandemic was associated with an increased incidence of preterm births in Brazil.
- The pandemic exacerbated regional disparities in preterm birth rates across Brazil.
- Further research is needed to understand the specific factors contributing to these regional variations.
Abstract:
The SARS-CoV-2 (COVID-19) pandemic impacted the health systems between and within countries, and in the course of the pandemic sexual and reproductive health services were the most disrupted. Findings from high-income settings have reported significant changes in preterm birth prevalence during the pandemic period. To understand the possible effects of the COVID-19 pandemic on preterm birth numbers at the Brazilian national level. We compare the number of preterm deliveries during the COVID-19 pandemic period (2020 and 2021) with previous years. We conducted a population-based cross-sectional study taking the period from January 2017 to December 2021 to account. We use individual-level live births data from the Brazilian Live Birth Information System (SINASC), and we estimate the odds ratio (OR) of preterm deliveries using propensity score weighting analysis in Brazil and its regions. During the study period (from 2017 to 2021), about 2.7 million live births were recorded per year, and the missing value for gestational age at delivery was less than 1.5%. The preterm birth prevalence slightly increased during the COVID-19 pandemic compared to the pre-pandemic period (11.32% in 2021 vs 11.09% in 2019, p-value < 0.0001). After adjusting for sociodemographic variables, the OR of preterm births in Brazil has significantly increased, 4% in 2020 (OR: 1.04 [1.03-1.05] 95% CI, p-value < 0.001), and 2% in 2021(OR: 1.02 [1.01-1.03] 95% CI, p-value < 0.001), compared to 2019. At the regional level, the preterm birth pattern in the South, Southeast and Northeast regions show a similar pattern. The highest odds ratio was observed in the South region (2020 vs 2019, OR: 1.07 [1.05-1.10] 95% CI; 2021 vs 2019, OR: 1.03 [1.01-1.06] 95% CI). However, we also observed a significant reduction in the ORs of preterm births in the northern region during the COVID-19 pandemic (2020 vs 2019, OR: 0.96 [0.94-0.98] 95% CI) and (2021 vs 2019, OR: 0.97 [0.95-0.99] 95% CI). Our analysis shows that the pandemic has increased regional variation in the number of preterm births in Brazil in 2020 and 2021 compared to the pre-pandemic years.
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