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Blood pressure normative values in preterm infants during postnatal transition
1Division of Neonatology, Department of Pediatrics and Child Health, Rady Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada. yelsayed@exchange.hsc.mb.ca.
Pediatric Research
|September 4, 2023
Summary
Normative blood pressure reference values were established for preterm infants born before 29 weeks gestational age. These blood pressure trends gradually increase during the first three days after birth, aiding in hemodynamics assessment.
Area of Science:
- Neonatal Physiology
- Pediatric Cardiology
- Clinical Pediatrics
Background:
- Normative blood pressure (BP) values in preterm infants during the critical postnatal transition period are not well-defined.
- Accurate BP reference values are essential for monitoring hemodynamics in vulnerable preterm neonates.
Purpose of the Study:
- To establish normative blood pressure reference values for preterm infants less than 29 weeks gestational age.
- To analyze BP trends during the postnatal transition in this population.
Main Methods:
- Inclusion of data from hemodynamically stable preterm infants (<29 weeks gestational age).
- Utilized blood pressure values exclusively from umbilical arterial catheter (UAC) monitoring.
- Employed regression analysis to identify gestational age and postnatal age as key determinants of BP.
Main Results:
- Data from 206 preterm infants were analyzed.
- Blood pressure demonstrated a gradual increase with advancing gestational age and over time during the postnatal transition.
- Established 5 BP centile values for various gestational age groups, showing typical BP fluctuations between the 5th and 75th centiles.
Conclusions:
- Gradual increases in BP are normal in stable preterm infants during postnatal transition; deviations may warrant hemodynamic assessment.
- These novel normative BP centile values, derived from invasive monitoring, provide a crucial tool for accurate hemodynamics monitoring in preterm infants.
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