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Bicarbonate secretion by rabbit proximal colon.

S K Sullivan, P L Smith

The American Journal of Physiology

|October 1, 1986

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The proximal colon actively transports bicarbonate, leading to luminal alkalinization. This process is sodium-dependent and influenced by adrenergic stimuli, suggesting a key role in colonic ion transport.

Area of Science:

Gastroenterology
Physiology
Cell Biology

Background:

The proximal colon plays a crucial role in fluid and electrolyte absorption.
Understanding ion transport mechanisms is vital for comprehending colonic function.

Purpose of the Study:

To investigate the mechanisms of luminal alkalinization in the proximal colon.
To elucidate the role of sodium and bicarbonate in this process.

Main Methods:

In vitro Ussing chamber studies on stripped proximal colon segments.
pH-stat technique to measure luminal alkalinization rates.
Ion-replacement studies and pharmacological inhibitors (ouabain, acetazolamide).

Main Results:

Proximal colon exhibits active luminal alkalinization (2.1 mu eq X h-1 X cm-2) dependent on serosal bicarbonate and glucose.

Related Experiment Videos

Luminal alkalinization is Na+-dependent and inhibited by ouabain, indicating active transport.

Epinephrine stimulates serosal alkalinization via a Na+-dependent mechanism.

Conclusions:

Luminal alkalinization is mediated by a Na+-dependent, active transcellular bicarbonate transport process.
A Na+-dependent bicarbonate absorptive process, activated by adrenergic stimuli, is implicated in colonic ion homeostasis.