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Updated: Jul 17, 2025

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Integrative Analysis of Androgen Receptor Interactors Aberrations and Associated Prognostic Significance in Prostate

Zhu Wang1, Ying Zhang2, Qiong Deng3

  • 1Urology Department, Affiliated Hospital of Longhua Shenzhen, Southern Medical University, Shenzhen, Guangdong 518109, China. wangzhu1223@hotmail.com.

Urology Journal
|September 5, 2023
PubMed
Abstract

Insights

Aberrations in androgen receptor (AR) interactors are linked to poor prognosis in advanced prostate cancer. These AR interactors may serve as biomarkers for diagnosing and understanding metastatic castration-resistant prostate cancer (CRPC).

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Significant advancements have been made in targeting the androgen receptor (AR) pathway for prostate cancer treatment.
  • However, the development of AR-interactor-related metastatic castration-resistant prostate cancer (CRPC) remains a clinical challenge.

Purpose of the Study:

  • To characterize AR-interactor aberrations in advanced prostate cancer.
  • To investigate the therapeutic implications of these aberrations.

Main Methods:

  • Utilized the STRING database, UALCAN web portal, and cBioPortal platform to analyze the AR interaction network, gene alterations, and prognostic significance.
  • Performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis for functional enrichment of AR-interactors.

Main Results:

  • Identified ten first-shell AR-interactors, with FOXA1 and PELP1 significantly upregulated, and CCND1, CTNNB1, NCOA4, and HSP90AA1 significantly downregulated.
  • The median survival for the altered group (n=227) was 70 months, compared to 141 months for the non-altered group (n=545) (P < 0.001).
  • Enrichment analysis revealed AR-interactors are notably enriched in prostate cancer, thyroid hormone signaling, and endocrine resistance pathways.

Conclusions:

  • AR-interactors show potential as diagnostic and prognostic markers for prostate cancer.
  • These findings offer new insights into the molecular mechanisms driving CRPC progression.

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