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Updated: Jul 17, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Photoinduced Borylation of the Inert C(sp3)-O Bond of Alkyl Heteroaryl Ethers
Hua Wang1, Jing-Feng Zhao1, Xing-Li Zhu1
1Department of Chemistry, School of Pharmacy, Air Force Medical University, Xi'an, Shaanxi 710032, People's Republic of China.
Abstract:
A photoinduced reductive Calkyl-O borylation of alkyl heteroaryl ethers with very negative reduction potential in the presence of 4-dimethylaminopyridine (DMAP) and bis(catecholato)diborane(B2cat2) was developed. Despite the high reducing power, various substrates with liable functional groups were well-tolerated as well as ethers derived from natural products and medicinal-relevant compounds. Mechanistic investigation implied that an intra-single electron transfer process in an electron donor-acceptor complex formed from ethers with the adduct of B2cat2 and DMAP should be involved.
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