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A Current Management Strategy for Children with Chronic Viral Hepatitis B, Based on International and National

Inna M Nesina1, Tetyana O Kryuchko1, Olha A Poda1

  • 1Department of Pediatrics No. 2, Poltava State Medical University, Poltava, Ukraine.

Journal of Mother and Child
|September 5, 2023
PubMed

Insights

Chronic hepatitis B in children remains a challenge due to complex pathogenesis and insufficient vaccination rates. Current treatments offer limited success, impacting global health strategies for viral hepatitis B.

Area of Science:

  • Pediatrics
  • Hepatology
  • Infectious Diseases

Background:

  • Chronic hepatitis B in children presents significant medical and social challenges.
  • Unresolved issues include pathogenesis, occult infections, viral clearance, and pediatric immune responses.

Purpose of the Study:

  • To review current diagnostic and treatment strategies for chronic hepatitis B in children.
  • Focuses on international and national guidelines.

Main Methods:

  • Review of international and national guidelines.
  • Analysis of pathogenesis and disease course.

Main Results:

  • Chronic hepatitis B involves a complex interplay between the virus, patient's immune system, and host factors.
  • This interaction influences disease phases and antiviral treatment outcomes.

Conclusions:

  • Inadequate hepatitis B vaccination in Ukraine fuels ongoing viral hepatitis B spread.
  • Antiviral therapies provide functional cure for few; current Ukrainian healthcare challenges may hinder WHO goals.
Abstract

Keywords:
childrenchronic hepatitis Bdiagnosishepatitis B virusmanagementpreventiontreatment

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