Analysis and Visualization of Longitudinal Genomic and Clinical Data from the AACR Project GENIE Biopharma...

Area of Science:

• Genomics and Bioinformatics
• Oncology
• Data Science

Background:

• International cancer registries collect valuable real-world genomic and clinical data.
• Joint analysis of these diverse datasets presents significant challenges for researchers.
• AACR Project GENIE aggregates data from 19 cancer centers, making over 130,000 patient records publicly available.

Purpose of the Study:

• To enhance the cBioPortal for Cancer Genomics platform to support the analysis of linked clinico-genomic data.
• To enable interactive investigation of longitudinal clinical and genomic information for cancer patients.
• To facilitate discoveries regarding the impact of genomic variants on cancer prognosis and treatment sensitivity.

Main Methods:

• Significant functional enhancements were made to the cBioPortal.
• Features include patient-level visualization of longitudinal clinical and genomic data with timelines.
• New capabilities allow sample selection based on treatment status and survival analysis by treatment regimen.

Main Results:

• The enhanced cBioPortal now supports interactive visualization and analysis of rich, linked clinico-genomic datasets.
• Users can compare molecular and clinical attributes before and after specific treatments.
• Survival analysis can be performed based on individual patient treatment regimens.

Conclusions:

• The improved cBioPortal provides a powerful toolkit for investigating complex cancer clinico-genomic data.
• These enhancements facilitate hypothesis generation and discovery in cancer research.
• The platform effectively supports exploration of data from AACR Project GENIE Biopharma Collaborative and similar initiatives.