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Updated: Jul 17, 2025

In vitro Assessment of Cardiac Reprogramming by Measuring Cardiac Specific Calcium Flux with a GCaMP3 Reporter
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In vitro Assessment of Cardiac Reprogramming by Measuring Cardiac Specific Calcium Flux with a GCaMP3 Reporter

Published on: February 22, 2022

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Cardiac Metabolism, Reprogramming, and Diseases

Haichang Wang1, Min Shen2, Xiaofei Shu2

  • 1Heart Hospital, Xi'an International Medical Center, Xi'an, China.

Journal of Cardiovascular Translational Research
|September 5, 2023
PubMed

Insights

Cardiovascular diseases (CVD) are a leading cause of death globally. This review explores how metabolic changes, or reprogramming, in the heart contribute to CVD, offering new treatment insights.

Area of Science:

  • Biochemistry
  • Pathology
  • Cardiology

Background:

  • Cardiovascular diseases (CVD) represent the primary cause of mortality worldwide.
  • The increasing incidence and prevalence of CVD necessitate urgent interventions.
  • Dysregulated metabolism is a critical factor in cardiovascular pathogenesis, potentially preceding other mechanisms.

Purpose of the Study:

  • To review cardiovascular metabolism and metabolic remodeling in various CVD subsets.
  • To propose a new paradigm for understanding and treating cardiovascular diseases based on metabolic insights.

Main Methods:

  • Literature review of cardiovascular metabolism.
  • Analysis of metabolic remodeling in different cardiovascular disease conditions.
  • Synthesis of current knowledge on heart metabolism under physiological and pathological states.

Main Results:

  • The healthy heart primarily utilizes fatty acids for energy via mitochondrial oxidative phosphorylation.
  • Metabolic pathways and substrate preferences shift under pathological conditions, a process known as metabolic remodeling.
  • Understanding these metabolic shifts is crucial for comprehending CVD progression.

Conclusions:

  • Metabolic remodeling is a key feature across different cardiovascular diseases.
  • Targeting metabolic pathways presents a promising therapeutic strategy for CVD.
  • A comprehensive understanding of cardiovascular metabolism can lead to novel treatment approaches.

Keywords:
Branched-chain amino acidsCardiac metabolismCardiovascular diseasesFatty acidsGlucoseKetone bodiesMetabolic reprogramming

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