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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Updated: Jul 17, 2025

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Psoriasis: Striving for Potential Biomarkers.

Deblina Dan1, Nimisha Srivastava1

  • 1Department of Pharmaceutics, Amity Institute of Pharmacy, Lucknow, Amity University Uttar Pradesh, Noida, India.

Assay and Drug Development Technologies
|September 5, 2023
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Summary
This summary is machine-generated.

Psoriasis is a chronic skin disease affecting 2-3% of the population. This review covers its classification, biomarkers, pathogenesis, and advanced treatments like biologics targeting IL-17, IL-23, and TNF-α.

Keywords:
comorbiditiesdrug therapiesepigenomic biomarkerglycomic biomarkermetabolomic biomarkerpsoriasistranscriptomic biomarker

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Area of Science:

  • Dermatology and Immunology
  • Molecular Biology
  • Biomarker Discovery

Background:

  • Psoriasis is a chronic, multifactorial skin disease characterized by scaly patches, affecting 2-3% of the global population.
  • Associated comorbidities include cardiovascular disorders, metabolic syndrome, and hypertension.
  • Molecular pathogenesis involves key cytokines like IL-17, IL-23, TNF-α, and CCL20, with Natural Killer (NK) cells contributing inflammatory cytokines.

Purpose of the Study:

  • To review the clinical classification and ideal characteristics of psoriasis biomarkers.
  • To provide an overview of biomarker discovery and validation methods.
  • To discuss recent advancements in psoriasis diagnosis and treatment, including molecular-targeted therapies.

Main Methods:

  • Literature review focusing on clinical classification, biomarker characteristics, discovery, and validation.
  • Analysis of molecular pathogenesis, including key cytokines and cell types.
  • Examination of current diagnostic and therapeutic strategies, including epigenomic, transcriptomic, glycomic, and metabolomic biomarkers.

Main Results:

  • Biomarkers for psoriasis diagnosis and treatment are available across epigenomic, transcriptomic, glycomic, and metabolomic profiles.
  • Molecular-targeted therapies, including biologics (TNF-α, IL-23, IL-17 antagonists) and oral agents (methotrexate, apremilast), demonstrate validated efficacy.
  • Specific biologic therapies like infliximab, adalimumab, guselkumab, risankizumab, secukinumab, and ixekizumab are effective.

Conclusions:

  • Recent advancements in molecular-targeted therapies offer effective treatment options for severe psoriasis symptoms.
  • Biomarker research is crucial for improving psoriasis diagnosis and guiding personalized treatment strategies.
  • Technological opportunities and challenges in psoriasis biomarker development and application require further investigation.