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Updated: Jul 17, 2025

Solid Plate-based Dietary Restriction in Caenorhabditis elegans
Published on: May 28, 2011
A step toward precision gerontology: Lifespan effects of calorie and protein restriction are consistent with
Ayşe Selcen Semerciöz-Oduncuoğlu1,2, Sharon E Mitchell2, Mustafa Özilgen1
1Department of Food Engineering, Faculty of Engineering, Yeditepe University, Istanbul 34755, Turkey.
Abstract:
Understanding aging is a key biological goal. Precision gerontology aims to predict how long individuals will live under different treatment scenarios. Calorie and protein restriction (CR and PR) extend lifespan in many species. Using data from C57BL/6 male mice under graded CR or PR, we introduce a computational thermodynamic model for entropy generation, which predicted the impact of the manipulations on lifespan. Daily entropy generation decreased significantly with increasing CR level, but not PR. Our predictions indicated the lifespan of CR mice should increase by 13 to 56% with 10 to 40% CR, relative to ad libitum-fed animals. This prediction was broadly consistent with the empirical observation of the lifespan impacts of CR in rodents. Modeling entropy fluxes may be a future strategy to identify antiaging interventions.
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