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Expansion of Anticomplement Therapy Indications from Rare Genetic Disorders to Common Kidney Diseases

Takashi Miwa1, Sayaka Sato1, Madhu Golla1

  • 1Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; email: miwataka@pennmedicine.upenn.edu, sayakas@pennmedicine.upenn.edu, madhub@pennmedicine.upenn.edu, songwe@pennmedicine.upenn.edu.

Annual Review of Medicine
|September 5, 2023
PubMed

Insights

Anticomplement therapies are shifting focus from rare diseases to common kidney diseases. This review highlights the growing importance of targeting complement overactivation for immune injury treatment.

Area of Science:

  • Immunology
  • Nephrology

Background:

  • The complement system is crucial for innate immunity.
  • Historically, research focused on complement deficiencies; now, overactivation is recognized as a cause of immune injury.
  • Kidneys are highly susceptible to complement-mediated damage.

Purpose of the Study:

  • To review the current status of anticomplement therapies.
  • To emphasize the expansion of these therapies from rare to common kidney diseases.

Main Methods:

  • Literature review of anticomplement therapies.
  • Analysis of complement overactivation mechanisms in kidney diseases.

Main Results:

  • Complement overactivation can stem from genetic mutations, autoantibodies, infections, or tissue stress.
  • Anticomplement therapies are being investigated for various kidney diseases.
  • Therapeutic strategies are evolving to address both rare and prevalent kidney conditions.

Conclusions:

  • Anticomplement therapies represent a promising avenue for treating immune-mediated kidney diseases.
  • The field is expanding to target more common renal pathologies beyond rare deficiencies.

Keywords:
C3 glomerulopathyIgA nephropathyatypical hemolytic uremic syndromechronic kidney diseasecomplementlupus nephritis

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