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Updated: Jul 17, 2025
Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
Published on: October 4, 2021
Dyskinesia and impulsive compulsive behaviour in Parkinson's disease are not related: Insights from a study with a
Lucia Ricciardi1, Andrea De Angelis1, Chiara Siri2
1Neurosciences Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK.
Introduction:
Previous studies have suggested an association between Impulsive Compulsive Behaviour (ICB) and dyskinesia in Parkinson's disease (PD). However, none of these studies have employed an objective home-based measure of dyskinesia.
Objectives:
To evaluate in advanced PD the relationship between ICB and dyskinesia, objectively measured with a wearable device.
Methods:
In this cross-sectional study, ICB and other neuropsychiatric symptoms were assessed by means of structured clinical interview and specific screening instruments. Presence and severity of motor fluctuations and dyskinesia were rated with patient's and clinician's based rating instruments. Motor fluctuations and dyskinesia were also measured at home for 5-days using a validated wearable devise, the Parkinson's KinetiGraph™(PKG).
Results:
We included 89 subjects with PD (29 females, 62 ± 7 years, disease duration 10.3 ± 4.5), of whom 36 (40%) had ICB. Patients with and without ICB did not differ by presence and severity of dyskinesia measured by clinical scales and PKG. There was no association between the presence of ICB and dyskinesia in the whole sample.
Conclusion:
Our data suggest that ICB and dyskinesia are common but unrelated disorders in advanced PD.
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