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Published on: August 7, 2017
Risk Factors for Acute Rhinosinusitis in Childhood Asthma
Hanrui Wang1,2,3, Jianwei Wang1,2,3, Zheying Song1,2,3,4
1Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.
Insights
Younger onset age and allergic sensitization to Dermatophagoides pteronyssinus (d1) are key risk factors for acute rhinosinusitis (ARS) in children with asthma. Early allergen intervention is crucial for managing ARS in this population.
Area of Science:
- Pediatric Allergy and Immunology
- Respiratory Medicine
- Clinical Epidemiology
Background:
- Infant infections linked to acute rhinosinusitis (ARS) are established risk factors for adolescent allergic asthma.
- However, specific risk factors for ARS onset in children already diagnosed with asthma remain poorly understood.
Purpose of the Study:
- To investigate and identify the primary risk factors associated with the onset of acute rhinosinusitis (ARS) in children diagnosed with asthma.
Main Methods:
- Retrospective analysis of clinical characteristics comparing asthmatic children with ARS (n=194) versus without ARS (n=799).
- Univariate and multivariate backward stepwise logistic regression analyses were employed to identify risk factors.
Main Results:
- Younger onset age and allergic sensitization to Dermatophagoides pteronyssinus (d1) were identified as independent risk factors for ARS in asthmatic children.
- Lower blood eosinophil (EOS) counts, total IgE levels, and reduced sensitization to Dermatophagoides species were observed in children with ARS.
Conclusions:
- Younger age at onset and sensitization to Dermatophagoides pteronyssinus (d1) are significant risk factors for ARS in childhood asthma.
- Proactive allergen intervention strategies should be implemented early in asthmatic children to mitigate ARS risk.
Introduction:
Specific pathogen infections associated with acute rhinosinusitis (ARS) in infants are risk factors for allergic asthma in adolescents. However, the risk factors for ARS onset remain largely unknown in asthmatic children. In this study, we aim to investigate the risk factors for ARS in childhood asthma.
Methods:
This study retrospectively compared and analyzed the clinical characteristics of asthmatic children with (n = 194) or without ARS (n = 799). Univariate regression analyses were performed to identify ARS-associated risk factors in asthmatic children, and subsequent multivariate backward stepwise logistic regression analyses were performed to identify independent risk factors.
Results:
The onset age, values of blood eosinophils (EOS) (%), and total IgE were significantly lower in patients with ARS than in those without ARS. Moreover, the proportions of patients allergic to Dermatophagoides pteronyssinus (d1) and Dermatophagoides farinae (d2) were significantly smaller in children with ARS (all p values <0.05). Univariate analyses showed that an older onset age, a higher body mass index, a higher value of blood EOS (%) were protective factors, while a higher value of blood lymphocytes (%) and a higher degree of sensitization to d1 and d2 were risk factors for ARS. Further backward stepwise multivariate logistic regression analyses confirmed that a younger onset age and allergic sensitization to d1 were independent risk factors for ARS in childhood asthma.
Conclusion:
Younger onset age and allergic sensitization to d1 are risk factors for the onset of ARS in childhood asthma, so allergen intervention should be performed as early as possible in asthmatic children.
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