Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

2.4K
Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
2.4K
Role of Septins01:02

Role of Septins

1.8K
Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
1.8K
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

6.8K
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved...
6.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Itgb1-Mediated Stabilization of Vimentin Alleviates Excessive Mechanical Stress-Induced Nucleus Pulposus Cell Pyroptosis and Intervertebral Disc Degeneration via PINK1-Parkin-Dependent Mitophagy.

Cell proliferation·2026
Same author

Cyberbullying victimization identification and large language model-assisted assessment: a study of cyberbullying victimization lexicon construction and validation.

Frontiers in psychiatry·2026
Same author

Potential Pathogenic Role of Glycine Receptor α1 Autoantibodies in Sporadic Creutzfeldt-Jakob Disease.

Clinical laboratory·2026
Same author

Incidence and risk factors of pseudoparesis in massive rotator cuff tears: a systematic review and meta-analysis.

BMC musculoskeletal disorders·2026
Same author

Detection and removal methods of antibiotic-resistance genes in drinking water sources: a review.

Journal of water and health·2026
Same author

From Environmental Exposure to Intervertebral Disc Degeneration: First Evidence of Pro-Degenerative Effects of Polyamide 6 Microplastics.

Biomedicines·2026

Related Experiment Video

Updated: Jul 17, 2025

Purification of Human S100A12 and Its Ion-induced Oligomers for Immune Cell Stimulation
12:55

Purification of Human S100A12 and Its Ion-induced Oligomers for Immune Cell Stimulation

Published on: September 29, 2019

6.0K

S100A6: molecular function and biomarker role.

Yidian Wang1, Xuewen Kang2,3,4, Xin Kang5

  • 1Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shanxi, China.

Biomarker Research
|September 5, 2023
PubMed
Summary

S100A6 protein regulates cell functions and interacts with various proteins. Its expression and role as a disease biomarker and therapeutic target are crucial in human health and stem cell research.

Keywords:
BiomarkerCell differentiationCellular stress responseCytoskeletonS100A6Stem cellsTumor

More Related Videos

Expression, Purification, and Antimicrobial Activity of S100A12
11:10

Expression, Purification, and Antimicrobial Activity of S100A12

Published on: May 13, 2017

8.4K
Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

1.5K

Related Experiment Videos

Last Updated: Jul 17, 2025

Purification of Human S100A12 and Its Ion-induced Oligomers for Immune Cell Stimulation
12:55

Purification of Human S100A12 and Its Ion-induced Oligomers for Immune Cell Stimulation

Published on: September 29, 2019

6.0K
Expression, Purification, and Antimicrobial Activity of S100A12
11:10

Expression, Purification, and Antimicrobial Activity of S100A12

Published on: May 13, 2017

8.4K
Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

1.5K

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • S100A6 (calcyclin) is a calcium-binding protein within the S100 protein family.
  • It plays roles in cytoskeleton dynamics, cellular stress responses, proliferation, and differentiation.
  • S100A6 interacts with numerous proteins in a calcium-dependent manner across various cellular compartments.

Purpose of the Study:

  • To review the S100A6 ligand interactions and transcriptional regulation.
  • To explore its molecular functions, including roles in the cytoskeleton, cell stress, and differentiation.
  • To highlight S100A6's significance as a biomarker in human diseases and stem cells.

Main Methods:

  • Literature review focusing on S100A6 protein.
  • Analysis of transcriptional regulation mechanisms involving factors like c-Myc, P53, and NF-κB.
  • Examination of epigenetic modifications (histone acetylation, DNA methylation) influencing S100A6 expression.

Main Results:

  • S100A6 expression is modulated by transcription factors and epigenetic mechanisms.
  • Its diverse functions are linked to cellular processes and protein interactions.
  • Differential S100A6 expression patterns are observed across various diseases and stages.

Conclusions:

  • S100A6 is a versatile protein with critical roles in cell biology.
  • Its expression is tightly regulated, influenced by cellular environment and epigenetic factors.
  • S100A6 holds potential as a diagnostic/prognostic biomarker and a therapeutic target in human diseases.