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Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...

Drug Delivery: Miscellaneous Routes

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...

Drug Delivery: Enteral Route

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.

Drug Delivery: Parenteral Route

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

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Tailored Drug Delivery Platforms: Stimulus-Responsive Core-Shell Structured Nanocarriers.

Yulong Shi¹, Yiran Zhang², Liangliang Zhu³

¹School of Materials and Chemistry & Institute of Bismuth and Rhenium, University of Shanghai for Science and Technology, Shanghai, 200093, China.

Advanced Healthcare Materials

|September 6, 2023

Summary

This summary is machine-generated.

Stimulus-responsive core-shell nanocarriers offer advanced drug delivery. This review details their design and controlled release mechanisms for smart therapeutic applications.

Keywords:

core-shell structures drug delivery systems nanocarriers stimulus-responsive

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Area of Science:

Materials Chemistry
Biomedicine
Nanotechnology

Background:

Core-shell nanocarriers are gaining attention for their unique properties and diverse applications.
Tailored core-shell structures represent a key area in developing smart drug delivery systems.
Systematic reviews on stimulus-responsive core-shell nanocarriers, focusing on design and release mechanisms, are limited.

Purpose of the Study:

To provide a comprehensive review of stimulus-responsive core-shell nanocarriers.
To categorize nanocarriers based on drug loading methods.
To highlight controlled release mechanisms via stimulus-response processes.

Main Methods:

Categorization of core-shell nanocarriers by drug payload.
Analysis of controlled release mechanisms triggered by environmental stimuli.
Discussion of design perspectives for core-shell nanocarriers as drug carriers.

Main Results:

Overview of various core-shell nanocarrier designs and their drug loading capabilities.
Detailed explanation of stimulus-responsive controlled release strategies.
Exploration of multifaceted design considerations for advanced drug delivery.

Conclusions:

Core-shell nanocarriers are promising for smart drug delivery.
Understanding stimulus-responsive mechanisms is crucial for optimizing nanocarrier design.
This review offers insights and future prospects for developing advanced nanocarriers.