Projection mapping system for laser speckle contrast image: feasibility study for clinical application.

Area of Science:

• Biomedical Optics
• Medical Imaging

Background:

• Laser speckle contrast imaging (LSCI) monitors blood flow perfusion.
• Conventional LSCI observation on monitors can cause spatial mismatch with the imaging region of interest (IROI).

Purpose of the Study:

• To develop and evaluate a projection mapping (PM) system for LSCIs (PMS_LSCI).
• To enable direct observation of blood flow perfusion within the IROI by projecting LSCIs.

Main Methods:

• The PMS_LSCI integrates a camera, optics, laser projector, and GUI software.
• Spatial matching was achieved by adjusting software and validated through in vitro and in vivo studies.
• Feasibility of real-time PM for LSCI was assessed in vivo.

Main Results:

• Spatial mismatch ranged from 2.74% to 6.47% based on surface curvature.
• The PMS_LSCI achieved real-time projection of LSCI across four distinct blood flow states.
• The system demonstrated clinical feasibility in both in vitro and in vivo settings.

Conclusions:

• The PMS_LSCI projects LSCI directly onto the IROI using a projector, eliminating monitor-based spatial mismatch.
• The developed system shows significant clinical potential for enhanced blood flow monitoring.