Chloramphenicol concentrations in calf muscle tissue.

Area of Science:

• Veterinary Pharmacology
• Animal Science
• Food Safety

Background:

• Chloramphenicol is an antibiotic used in veterinary medicine.
• Understanding drug residue in edible tissues is crucial for food safety and regulatory compliance.
• Limited data exists on chloramphenicol pharmacokinetics in young cattle.

Purpose of the Study:

• To determine chloramphenicol concentrations in calf muscle tissue.
• To evaluate the impact of different administration routes (IV and IM) and dosages on tissue residue.
• To provide data for establishing withdrawal times in cattle.

Main Methods:

• Twenty-five calves (9–11 weeks old) received two doses of chloramphenicol.
• Dosing regimens included intravenous (IV) and intramuscular (IM) routes at varying doses.
• Calves were euthanized at intervals from 2 to 72 hours post-administration for tissue collection.

Main Results:

• Chloramphenicol concentrations were quantified in muscle tissues collected post-euthanasia.
• Tissue residue levels varied based on administration route and time post-dose.
• Data on chloramphenicol depletion from calf muscle was generated.

Conclusions:

• The study provides essential pharmacokinetic data for chloramphenicol in calves.
• Findings contribute to risk assessment for antibiotic residues in beef products.
• This research supports informed decisions regarding chloramphenicol use and withdrawal periods in cattle.