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Controlling viral inflammatory lesions by rebalancing immune response patterns
Sachin Mulik1, Engin Berber2, Sharvan Sehrawat3
1Center for Biomedical Research, The University of Texas Health Science Center at Tyler, Tyler, TX, United States.
Frontiers in Immunology
|September 6, 2023
Summary
Viral infections can cause tissue damage primarily through the host
Area of Science:
- Immunology
- Virology
- Pathology
Background:
- Chronic viral infections often lead to tissue-damaging immunoinflammatory lesions.
- These lesions can be predominantly caused by the host's immune response rather than direct viral action.
Purpose of the Study:
- To review immune-modulating strategies for counteracting viral immunoinflammatory lesions.
- To explore the potential for rebalancing host responses to control virus-induced tissue damage.
Main Methods:
- Discussion of various immune-modulating approaches.
- Identification of host response aspects influencing immune patterns.
- Review of successful modulation strategies, primarily from model systems.
Main Results:
- Viral lesions are often a consequence of host immune responses.
- Host responses contain both damaging and resolving components.
- Modulating immune activity can lead to control of inflammatory lesions.
Conclusions:
- Rebalancing immune responses offers a strategy to diminish or control viral lesions.
- Therapeutic approaches targeting immune modulation show promise for clinical translation.
- Controlling inflammatory lesions in viral infections is achievable through immune modulation.
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