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Pseudomonas cepacia: decrease in colonization in patients with cystic fibrosis.

M J Thomassen, C A Demko, C F Doershuk

    The American Review of Respiratory Disease
    |October 1, 1986
    PubMed
    Summary
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    Pseudomonas cepacia colonization increased in cystic fibrosis (CF) patients. Implementing infection control measures, like patient separation, significantly reduced new cases, suggesting patient-to-patient transmission.

    Area of Science:

    • Medical Microbiology
    • Infectious Diseases
    • Pulmonology

    Background:

    • Increasing incidence and prevalence of Pseudomonas cepacia pulmonary colonization in cystic fibrosis (CF) patients.
    • Previous studies suggested sibling transmission and association with hospitalization.
    • Uncertainty regarding transmission routes necessitated precautionary measures.

    Purpose of the Study:

    • To investigate the source and mode of Pseudomonas cepacia transmission in CF patients.
    • To evaluate the effectiveness of implemented infection control measures.

    Main Methods:

    • Instituted limited precautionary measures in 1983, including patient segregation, staff re-education, family communication, and separate summer camps.
    • Conducted repeated environmental cultures for P. cepacia.

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    Main Results:

    • Environmental cultures were negative for P. cepacia.
    • A sharp decline in P. cepacia incidence was observed following the implementation of control measures (8.2% in 1983 to 1.7% in 1984).

    Conclusions:

    • Results suggest patient-to-patient transmission of P. cepacia.
    • Continued segregation measures are recommended due to the association of P. cepacia with reduced survival in CF patients.