FGFR Inhibition: Understanding and Overcoming Resistance

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Abhishek Tripathi1, Daneng Li1, Sumanta K Pal1

  • 1Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, California.

Cancer Discovery
|September 6, 2023
PubMed
Abstract

Insights

Fibroblast growth factor receptor (FGFR) inhibitors face evolving resistance through mutations and signaling pathway activation. A new FGFR2-selective inhibitor, RLY-4008, shows promise in overcoming resistance and reducing toxicity.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Fibroblast growth factor receptor (FGFR) inhibitors are crucial in cancer therapy.
  • Resistance to FGFR inhibitors develops through mechanisms like kinase domain mutations and PI3K-AKT pathway activation.
  • Understanding these resistance mechanisms is vital for developing more effective treatments.

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