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Related Experiment Video

Updated: Jul 17, 2025

A Personalized 3D-Printed Model for Preoperative Evaluation in Thyroid Surgery
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ThyroidPrint®: clinical utility for indeterminate thyroid cytology.

Roberto Olmos1, José Miguel Domínguez1, Sergio Vargas-Salas2

  • 1Department of Endocrinology, School of Medicine Pontificia Universidad Católica de Chile.

Endocrine-Related Cancer
|September 6, 2023
PubMed
Summary
This summary is machine-generated.

ThyroidPrint® molecular testing helps doctors avoid unnecessary surgeries for indeterminate thyroid nodules (ITNs). This study shows it reduced diagnostic surgeries by 67% in ITN patients, favoring active surveillance for benign results.

Keywords:
clinical utilitygenetic classifierindeterminate thyroid cytology

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Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Diagnostics

Background:

  • Indeterminate thyroid nodules (ITNs) pose diagnostic challenges, often requiring surgery to rule out malignancy.
  • Molecular testing offers a potential solution to improve ITN diagnosis and guide clinical decisions.
  • ThyroidPrint® is a ten-gene classifier designed to identify benign ITNs, reducing the need for invasive procedures.

Purpose of the Study:

  • To evaluate the clinical utility and impact of ThyroidPrint® on physician decision-making for patients with ITNs.
  • To assess the real-world effectiveness of ThyroidPrint® in reducing diagnostic surgeries for ITNs.
  • To determine the benign call rate (BCR) and malignancy rate in surgically confirmed cases.

Main Methods:

  • A prospective, single-center, noninterventional clinical utility study was conducted.
  • Physicians' decisions regarding ITN management were analyzed before and after ThyroidPrint® testing.
  • Data collected included nodule characteristics, molecular test results, BCR, and histopathological outcomes from surgery.

Main Results:

  • The study included 1272 fine-needle aspirations, with 109 (8.6%) Bethesda III and 135 (10.6%) Bethesda IV ITNs.
  • Molecular testing was performed on 155 ITNs, yielding a 67.1% benign call rate (BCR).
  • Physicians opted for active surveillance in 99% of patients with benign ThyroidPrint® results, reducing diagnostic surgery by 67% for ITNs.

Conclusions:

  • ThyroidPrint® effectively aids physicians in managing indeterminate thyroid nodules, significantly decreasing the rate of diagnostic surgeries.
  • The molecular classifier demonstrates high utility in guiding clinical decisions, promoting active surveillance for benign-classified nodules.
  • This study validates the real-world clinical benefit of ThyroidPrint® in optimizing patient care for ITNs.