Hypervirulent Klebsiella pneumoniae detection methods: a minireview

Area of Science:

• Microbiology
• Infectious Diseases
• Public Health

Background:

• Hypervirulent Klebsiella pneumoniae (hvKp) poses a significant global health threat due to its high virulence and epidemic potential.
• Early and rapid detection of hvKp is essential for effective treatment and prevention strategies.

Purpose of the Study:

• To conduct a retrospective review of hvKp detection methods published between 2012 and 2022.
• To summarize and analyze traditional and biomarker-based detection technologies for hvKp.
• To identify challenges and future directions in hvKp detection.

Main Methods:

• Literature search on ScienceDirect, Google Scholar, and PubMed using keywords like 'Hypervirulent Klebsiella pneumoniae,' 'biomarkers,' and 'detection techniques.'
• Retrospective analysis focusing on traditional detection assays and biomarker-based approaches.
• Systematic review of research papers from 2012-2022.

Main Results:

• Various detection methods exist, including String test, Galleria mellonella infection test, PCR, and isothermal exponential amplification.
• Both traditional and biomarker-based methods have distinct advantages and limitations.
• The review highlights the need for improved and faster diagnostic tools.

Conclusions:

• Advancements in hvKp detection are critical for managing its public health impact.
• Further research into novel biomarkers and rapid detection technologies is warranted.
• This review provides a reference for developing future hvKp diagnostic strategies.