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Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
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Related Experiment Video

Updated: Jul 17, 2025

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[Relationships between microbiome and neurodegeneration].

Corinna Bang1, Sebastian Heinzel2,3

  • 1Institut für Klinische Molekularbiologie (IKMB), Universitätsklinikum Schleswig-Holstein (UKSH), Christian-Albrechts-Universität zu Kiel, Kiel, Deutschland. c.bang@ikmb.uni-kiel.de.

Der Nervenarzt
|September 6, 2023
PubMed
Summary

Gut microbiome alterations, or dysbiosis, are linked to neurodegenerative diseases like Parkinson's and Alzheimer's. Further research may offer new therapeutic strategies targeting the microbiome.

Keywords:
Alzheimerʼs diseaseGut bacteriaGut-brain axisParkinsonʼs diseaseTherapeutic options

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Area of Science:

  • Microbiology
  • Neuroscience
  • Gastroenterology

Context:

  • Neurodegenerative diseases, including Parkinson's disease (PD) and Alzheimer's disease (AD), are increasingly associated with alterations in the gut microbiome.
  • Studies indicate that changes in gut microbial composition may occur even in the early, prodromal stages of these conditions.

Purpose:

  • To provide an overview of the current evidence linking microbial changes to the development of PD and AD.
  • To analyze and evaluate the existing literature on the gut microbiome's role in neurodegeneration.

Summary:

  • Patients with PD and AD exhibit gut dysbiosis, characterized by a reduction in short-chain fatty acid-producing bacteria.
  • These microbial shifts are associated with systemic inflammation, impaired intestinal and blood-brain barrier integrity, and the potential involvement of bacterial molecules like lipopolysaccharides and curli.
  • Oral bacteria may also contribute to Alzheimer's disease pathogenesis.

Impact:

  • The findings highlight the complex relationship between the gut microbiome and neurodegenerative diseases, suggesting potential therapeutic targets.
  • Understanding the causality of dysbiosis is crucial for developing novel strategies to prevent or manage these debilitating conditions.