Related Experiment Video

Updated: Jul 17, 2025

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

6.1K

Pesticide exposure and risk of Central Nervous System tumors in children: a systematic review with meta-analysis

Anne Lívia Cavalcante Mota1, Isadora Marques Barbosa1, Andrea Bezerra Rodrigues2

  • 1Programa de Pós- Graduação em Cuidados Clínicos em Enfermagem e Saúde, Universidade Estadual do Ceará (UECE). Av. Dr. Silas Munguba 1700, Campus do Itaperi. 60714-903 Fortaleza CE Brasil. aliviacante@gmail.com.

Ciencia & Saude Coletiva
|September 6, 2023
PubMed

Insights

Childhood central nervous system (CNS) tumors may be linked to pesticide exposure. This systematic review found evidence associating pesticide exposure with astrocytomas in children.

Area of Science:

  • Environmental epidemiology
  • Pediatric oncology
  • Toxicology

Background:

  • Central Nervous System (CNS) tumors are the most common childhood malignant neoplasms.
  • Understanding environmental risk factors for pediatric CNS tumors is crucial for prevention and early detection.

Approach:

  • Systematic review and meta-analysis of cohort and case-control studies.
  • Searched multiple databases (PubMed/MEDILINE, Embase, Web of Science, Scopus, CINAHL).
  • Included studies on children aged 0-14 years with exposure to pesticides and CNS tumors.

Key Points:

  • A significant association was found between pesticide exposure and astrocytomas (OR 1.50; 95%CI 1.15-1.96; p=0.03).
  • The review synthesized evidence from 14 selected studies out of 1,158 initially identified.
  • The findings suggest a link between pesticide exposure and specific types of childhood CNS tumors.

Conclusions:

  • Environmental pesticide exposure is associated with an increased risk of developing certain childhood Central Nervous System tumors, particularly astrocytomas.
  • Further research is warranted to elucidate specific pesticide classes and exposure pathways contributing to pediatric CNS tumor development.

More Related Videos

Examining the Effect of Pesticides on Caenorhabditis elegans Neurons05:08

Examining the Effect of Pesticides on Caenorhabditis elegans Neurons

Published on: May 27, 2022

2.4K
Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays08:28

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Published on: April 26, 2018

6.0K

Related Concept Videos

Types of Toxins01:36

Types of Toxins

Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.8K
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.5K
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.3K
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
109
Toxic Reactions: Overview01:26

Toxic Reactions: Overview

When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
1.0K