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Atezolizumab for Advanced Alveolar Soft Part Sarcoma
Alice P Chen1, Elad Sharon1, Geraldine O'Sullivan-Coyne1
1From the Division of Cancer Treatment and Diagnosis (A.P. Chen, E.S., G.O.-C., N.M., J.C.F., A.R.N., N.T., L.K.F., C.L.R., J.H.D.) and the Center for Cancer Research (J.G., J.H.D.), National Cancer Institute, Bethesda, the Clinical Pharmacodynamics Biomarker Program, Applied and Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick (K.K.F., B.L.M., D.F.W., A.B., K.V.F.-G., R.E.P.), and the Department of Oncology, Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore (B.H.L.) - all in Maryland; the Division of Oncology, University of Southern California Norris Comprehensive Cancer Center, Los Angeles (J.S.H.); the Division of Oncology, Washington University School of Medicine in St. Louis, St. Louis (B.A.V.T.); the University of Texas M.D. Anderson Cancer Center, Houston (A.P. Conley); Emory University, Atlanta (W.L.R.); Duke Cancer Institute, Duke University Medical Center, Durham, NC (R.F.R.); University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh (M.A.B.); the Division of Hematology-Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville (E.J.D.); the Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston (P.M.); the Department of Internal Medicine, Section of Medical Oncology, Yale University School of Medicine, New Haven, CT (H.A.D.); the Division of Hematology and Oncology, Department of Medicine, Columbia University Irving Medical Center, New York (G.K.S.); Mayo Clinic, Rochester, MN (S.H.O.); the Division of Pediatric Hematology-Oncology, University of Nebraska Medical Center, Omaha (J.C.B.); the Division of Medical Oncology, Department of Internal Medicine, Ohio State University, Columbus (J.L.C.); and Stephenson Cancer Center at the University of Oklahoma, Oklahoma City (A.R.N.).
Atezolizumab shows promise for advanced alveolar soft part sarcoma (ASPS), a rare cancer with no standard treatment. This study found sustained responses in about a third of patients, offering new hope for ASPS treatment.
Area of Science:
- Oncology
- Immunotherapy
- Rare Cancers
Background:
- Alveolar soft part sarcoma (ASPS) is a rare soft-tissue sarcoma with a poor prognosis and no established therapies.
- Immune checkpoint inhibitors have recently shown encouraging responses in ASPS patients.
Purpose of the Study:
- To evaluate the efficacy and safety of atezolizumab, an anti-programmed death ligand 1 (PD-L1) agent, in patients with advanced ASPS.
Main Methods:
- A phase 2, multicenter, single-group study involving adult and pediatric patients with advanced ASPS.
- Atezolizumab was administered intravenously every 21 days.
- Objective response, duration of response, and progression-free survival were assessed using RECIST v1.1 criteria.
Main Results:
- Objective responses were observed in 37% of 52 patients (1 complete, 18 partial responses).
- Median duration of response was 24.7 months, and median progression-free survival was 20.8 months.
- Responses were sustained even after treatment breaks, and no treatment-related grade 4 or 5 adverse events occurred.
Conclusions:
- Atezolizumab demonstrated efficacy in inducing sustained responses in approximately one-third of patients with advanced ASPS.
- This finding suggests atezolizumab as a potential therapeutic option for advanced ASPS.
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