Related Experiment Video
Updated: Jul 17, 2025
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
11.5K
Risk factors and immunological biomarkers in denture stomatitis: An observational cross-sectional study
Lorena Mosconi Clemente1, Adriana Barbosa Ribeiro2, Caroline Vieira Fortes1
1Department of Dental Materials and Prosthesis, School of Dentistry of Ribeirao Preto, University of São Paulo (USP), Ribeirão Preto, Brazil.
Archives of Oral Biology
|September 6, 2023
Summary
Increased Candida species load on dentures and palate is strongly linked to Denture Stomatitis (DS). Interleukin-6 (IL-6) may play a role in local signaling associated with DS severity.
Area of Science:
- Oral medicine
- Immunology
- Microbiology
Background:
- Denture Stomatitis (DS) is a common oral condition affecting denture wearers.
- Understanding the risk factors and immunological markers associated with DS is crucial for effective management.
Purpose of the Study:
- To assess sociodemographic, behavioral, and clinical risk factors for Denture Stomatitis (DS).
- To evaluate local and systemic immunological biomarkers, including cytokine and C-reactive protein levels, in individuals with and without DS.
- To investigate the microbial load of various species, including Candida spp., in relation to DS severity.
Main Methods:
- An observational transversal study involving 76 participants categorized into three groups: healthy (Group 0), moderate DS (Group 1), and severe DS (Group 2).
- Assessment included sociodemographic, behavioral, and clinical parameters, microbial analysis (Candida spp., Staphylococcus spp., Streptococcus mutans, Pseudomonas spp., enterobacteria), and measurement of salivary IL-6 and C-reactive protein.
- Statistical analysis employed ANOVA, Fisher's exact, Kruskal-Wallis, Mann-Whitney, Wilcoxon, and Pearson's chi-square tests.
Main Results:
- Higher microbial load of Candida albicans on dentures and Candida spp. on the palate were significantly associated with moderate and severe DS (Groups 1 and 2) compared to healthy individuals (Group 0).
- Salivary IL-6 levels were elevated in participants with moderate DS (Group 1) and intermediate in severe DS (Group 2) compared to the healthy group.
- No significant differences were found in C-reactive protein levels or most bacterial loads among the groups. Age and denture age showed no correlation with DS severity.
Conclusions:
- The microbial load of Candida species is the most significant factor associated with Denture Stomatitis.
- Interleukin-6 (IL-6) appears to be involved in local signaling pathways related to the severity of Denture Stomatitis.
