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Updated: Jul 17, 2025

A Novel Pavlovian Fear Conditioning Paradigm to Study Freezing and Flight Behavior
Published on: January 5, 2021
Fight, flight, and freeze!
Riya Keshri1, Julie Mathieu2, Hannele Ruohola-Baker1
1Department of Biochemistry, University of Washington, Seattle, WA, USA; Institute for Stem Cell & Regenerative Medicine, University of Washington, Seattle, WA, USA.
Abstract:
Just like time and tide, embryonic development waits for no man but progresses forcefully to its completion, with just one exception. Diapause is an enigmatic, reversible, dormant halt that protects the developing embryo. Cancer cells have evolved to hijack many useful stem cell capabilities, and diapause is no exception. Recent work has revealed a diapause-like cancer cell state, prompting the quest for its key molecular regulators useful for cancer therapies. The present paper by Sun et al.1 addresses this knowledge gap by revealing a key player in regulating the diapause-like cancer cell stage, the condensin protein SMC4.
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