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Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
Published on: February 18, 2022
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Perfused and Nonperfused Microaneurysms Identified and Characterized by Structural and Angiographic OCT.
Min Gao1, Tristan T Hormel1, Yukun Guo2
1Casey Eye Institute, Oregon Health & Science University, Portland, Oregon.
Ophthalmology. Retina
|September 6, 2023
Summary
Fully perfused microaneurysms (MAs) identified with OCT angiography are more likely to be associated with diabetic macular edema (DME). This finding helps understand MA characteristics and their link to DME in diabetic retinopathy.
Area of Science:
- Ophthalmology
- Medical Imaging
- Diabetic Retinopathy Research
Background:
- Microaneurysms (MAs) are key indicators in diabetic retinopathy (DR).
- Their structural characteristics on optical coherence tomography (OCT) and flow on OCT angiography (OCTA) are distinct.
- The quantitative relationship between MAs and macular edema in DR remains underexplored.
Purpose of the Study:
- To quantitatively explore the relationship between microaneurysms and regional macular edema in diabetic retinopathy.
- To classify microaneurysms based on OCT and OCTA findings and assess their association with diabetic macular edema.
Main Methods:
- Retrospective cross-sectional study of 99 participants with diabetic retinopathy.
- Utilized OCT and OCTA for MA identification and classification into fully perfused, partially perfused, and nonperfused types.
- Compared OCT-based MA detection with fundus photography and fluorescein angiography.
Main Results:
- 308 MAs were identified, with 166 fully perfused, 88 partially perfused, and 54 nonperfused.
- Fully perfused MAs showed a higher likelihood of association with local retinal fluid compared to other types.
- OCT/OCTA detected all MAs visible on fundus photography, and some OCT-identified MAs were not visible on fluorescein angiography.
Conclusions:
- Microaneurysms with colocalized flow on OCTA are more strongly associated with diabetic macular edema (DME).
- This classification aids in understanding MA contribution to DME development in DR.
