Related Experiment Video
Updated: Jul 17, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Rituximab for the treatment of acute exacerbation of interstitial lung disease associated with connective tissue
Francisco León Román1, Beatriz Pintado-Cort2, Diana García-Casado3
1Pulmonology Department, Hospital Recoletas Campo Grande, Valladolid, Spain franciscoleonroman19@gmail.com.
Background:
Acute exacerbation of interstitial lung disease (AE-ILD) is a severe complication with a poor prognosis. No clinical trials have supported the use of rituximab in AE-ILD associated with connective tissue disease.
Methods:
We present a series of four cases in which administration of rituximab was associated with appropriate clinical, radiological and functional progress.
Results:
The four patients were alive 30 days after discharge following their exacerbation.
Conclusions:
Given the speed of action, safety and efficacy profile observed for rituximab, we believe that this agent should be further investigated in clinical trials so that it could be included in the daily clinical management of this severe condition.
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