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Susceptibility of Campylobacter pyloridis to three macrolide antibiotics (erythromycin, roxithromycin [RU 28965], and

S Czinn, H Carr, S Aronoff

    Antimicrobial Agents and Chemotherapy
    |August 1, 1986
    PubMed

    Insights

    Three macrolide antibiotics, including erythromycin, showed strong inhibitory activity against Campylobacter pyloridis, a bacterium linked to peptic ulcers. These macrolides are promising for treating C. pyloridis infections.

    Area of Science:

    • Microbiology
    • Pharmacology
    • Gastroenterology

    Background:

    • Campylobacter pyloridis (C. pyloridis) presence in gastric mucosa is associated with peptic ulcer disease.
    • Understanding antimicrobial susceptibility is crucial for effective treatment strategies.

    Purpose of the Study:

    • To evaluate the in vitro inhibitory activity of macrolide compounds and rifampin against clinical isolates of C. pyloridis.
    • To compare the efficacy of erythromycin, roxithromycin, and CP 62,993 against C. pyloridis.

    Main Methods:

    • Minimum Inhibitory Concentrations (MICs) were determined for three macrolides and rifampin.
    • Ten clinical isolates of C. pyloridis were used for susceptibility testing.

    Main Results:

    • Macrolide compounds (erythromycin, roxithromycin, CP 62,993) demonstrated potent and comparable activity against C. pyloridis strains.
    • MICs for macrolides ranged from 0.06 to 0.5 microgram/ml.
    • Rifampin exhibited lower activity, with MICs ranging from 0.25 to >1 microgram/ml.

    Conclusions:

    • Erythromycin and novel macrolide derivatives show significant potential as therapeutic agents for C. pyloridis infections.
    • Macrolides are effective against C. pyloridis, suggesting their utility in managing associated peptic ulcer disease.

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